Diseases Associated With Inclusion Bodies
Although storing cellular metabolites can serve a positive function for human cells, a deviation in natural balance can lead to certain disorders or health problems. Inclusion bodies cannot be confused with amyloid bodies which are also protein aggregates. The main difference is that amyloid accumulation involves polymerisation and can be intra or extracellular. However, inclusion bodies do not mandatorily need polymerisation and are specifically intracellular. Extracellular accumulations are not considered inclusion bodies.
Here, we have mentioned the human diseases involving inclusion bodies:
- Neuron and Muscle-Related Diseases: Occur when inclusion bodies or misfolded protein aggregates accumulate in the cytoplasm or nucleus of neurons. Examples include Huntington’s disease, Parkinson’s disease, dementia, and myositis.
- Erythrocyte-Related Diseases: RBCs do not contain inclusion bodies in general. But sometimes, they may accumulate in case of an existing pathological condition. Examples include alpha thalassemia and protozoan infections like malaria and babesemia.
- Viral infection-related diseases: These diseases occur due to the accumulation of basophilic or acidophilic inclusion bodies within plant or animal cells. Examples include smallpox, fowlpox, yellow fever and rabies.
Inclusion Bodies
Inclusion bodies are also known as cytoplasmic inclusions, cell inclusions, or elementary bodies. Some inclusion bodies examples are Negri bodies, Lewy bodies, etc. They are found floating in the cytoplasm. These are usually formed in the cells if they experience stress or are infected. Inclusion bodies class 11 is an important topic in the biology syllabus.
The general features of inclusion bodies depict the inclusion bodies as being acidophilic. Inclusion bodies can be classified as to where and how they are formed. In this article, we will read about the Inclusion bodies meaning, features, functions, and diseases involving inclusion bodies.
Table of Content
- What are Inclusion Bodies?
- General Features of Inclusion Bodies in Cell
- Functions of Inclusion Bodies
- Classification of Inclusion Bodies
- Inclusion Bodies Examples
- Diseases Associated With Inclusion Bodies