Factors Affecting the Claisen Condensation
Factors affecting the Claisen condensation include:
- Nature of the Base: The choice of base is crucial, and it should be a strong base to facilitate the deprotonation and formation of the enolate ion. Typically, alkoxide bases that match the esters’ alkoxy group are used
- Solvent: The solvent used should not engage with the reagents or the base, such as ethanol or dimethyl sulfoxide (DMSO), to carry the reaction forward
- Reaction Temperature: The temperature at which the reaction is carried out can impact the rate of the reaction and the formation of the desired product
- Concentration of Reactants: The reactants’ concentration can influence the reaction’s yield and selectivity.
Claisen Condensation
Claisen condensation is an organic reaction that forms a new carbon-carbon bond, producing a β-keto ester. It involves the condensation of two esters or one ester and a carbonyl compound in the presence of a strong base, forming a β-keto ester or a β-diketone. It was discovered by German chemist Ludwig Claisen in 1887. In this article, we will look into What Claisen Condensation is, its mechanism, examples, types, etc.