What is Addison’s Disease?
Addison disease is the term used to describe the adrenocortical insufficiency that results from the destruction or functioning of the adrenal cortex. About 90% of both adrenal cortices have been damaged by the time the clinical symptoms start to show. The adrenal glands don’t produce enough cortisol and aldosterone when you have Addison’s disease, a chronic disorder.
The two small, triangular-shaped adrenal glands, or suprarenal glands, are situated on top of each of your two kidneys. The endocrine system in the body contains them. The body responds to stress, such as the stress of disease, injury, or surgery, with the aid of the hormone cortisol. Also, it supports the maintenance of blood pressure, heart health, immune system, and blood sugar (glucose) levels. Life needs cortisol to function.
Difference Between Addison’s Disease and Cushing’s Syndrome
The main distinction between Addison syndrome and Cushing’s disease is that Cushing’s syndrome exhibits an excess of cortisol while Addison’s disease exhibits a hormonal deficiency of cortisol and aldosterone. To correctly diagnose and treat Addison’s disease and Cushing’s syndrome, it’s critical to understand their differences. The hypofunction of the adrenal gland, which may be brought on by primary adrenocortical insufficiency or a lack of pituitary adrenocorticotropic hormone (ACTH) release, is the underlying cause of Addison’s disease. On the other hand, overproduction of the hormone cortisol in the body results in Cushing’s syndrome. Let’s have a glance at both topics in detail.