Difference of Riemer Tiemann Reaction With Other Reactions
Here are the brief differences between Riemer Tieman reaction with other famous reactions such as Gattermann reaction, Gattermann-Koch reaction, Vilsmeier-Haack reaction, and Duff reaction.
Reaction |
Reagents |
Conditions |
Products |
---|---|---|---|
Riemer Tiemann Reaction |
Chloroform (CHCI2) and Sodium Hydroxide (NaOH) |
The process of reaction takes place under alkaline conditions and requires heating |
Aromatic Aldehyde |
Gattermann Reaction |
Carbon Monoxide (CO), Hydrogen Chloride (HCI), Aluminimum Chloride (AICI2) |
The process of reaction takes place under high pressure conditions and at elevated temp |
Aromatic Aldehyde |
Gatterman-Koch Reaction |
Carbon Monoxide (CO), Hydrogen Chloride (HCI), Aluminimum Chloride (AICI2) |
The process of reaction takes place under high pressure conditions and at elevated temp |
Aromatic Aldehyde |
Vilsmeier-Haack Reaction |
Phosphorus Oxychloride (POCI3) |
The process of reaction takes place under milder conditions compared to the above two reactions |
Aromatic Aldehyde |
Duff Reaction |
Phosphorus Pentachloride (PCI5) |
The process of reaction takes place under anydrous and inert atmosphere conditions |
Aromatic Aldehyde |
Variations of Riemer Tiemann Reaction
The Riemer Tiemann reaction can be varied in so many ways. Here are some of the most common variations include:
- Different Bases: The reaction can be carried out with number of different bases such as potassium hydroxide (KOH) or sodium hydroxide (NaOH). It can help in yielding of the reaction. For example, using potassium hydroxide instead of sodium hydroxide can improve the yield of salicylaldehyde.
- Different Haloforms: The Riemer Tiemann reaction can be carried out with haloforms such as Carbon Tetrachloride (CCI4) or bromoform (CHBr3). It produces different ortho – hydroxybenzalyde depending on the different types of holoforms used in the reaction.
- Different Solvents: The reaction can also be made possible with using water or ethanol. It can help in yielding of the reaction. For example, using ethanol or water instead can improve the yield of salicylaldehyde.
Reimer Tiemann Reaction Mechanism
Riemer Tiemann’s Reaction is named after the pioneering discoveries of the 19th-century chemists Karl Riemer and Ferdinand Tiemann. Reimer-Tiemann reaction is a versatile and important reaction in organic chemistry, which is used for the introduction of carbonyl groups into aromatic compounds, making it a fundamental tool for the synthesis of various valuable organic molecules.
Reimer-Tiemann Reaction can be used to synthesize a variety of ortho-hydroxy benzaldehydes, which are important precursors to a variety of other products, such as pharmaceuticals, dyes, and flavorings. Let’s dig deeper into Riemer Tiemann’s reaction discovered by German scientists and explore its mechanism, applications, and more through this article.
Table of Content
- What is Riemer Tiemann Reaction?
- Mechanism of Riemer Tiemann Reaction
- Difference of Riemer Tiemann Reaction With Other Reactions
- Applications of Riemer Tiemann Reaction