What is Riemer Tiemann Reaction?
Reimer-Tiemann reaction is a chemical reaction used in organic chemistry for the synthesis of ortho-formyl substituted phenols from phenols. It involves the generation of an ortho-formyl substituted phenoxide from a phenol and subsequent reaction with a chloroform (CHCl3) in the presence of a strong base such as sodium hydroxide (NaOH) or potassium hydroxide (KOH).
The general reaction equation for the Riemer-Tiemann reaction is donated as follows:
Phenol (C6H5OH) + Chloroform (CHCl3) + Sodium Hydroxide (NaOH) → Salicylaldehyde
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Reimer Tiemann Reaction Mechanism
Riemer Tiemann’s Reaction is named after the pioneering discoveries of the 19th-century chemists Karl Riemer and Ferdinand Tiemann. Reimer-Tiemann reaction is a versatile and important reaction in organic chemistry, which is used for the introduction of carbonyl groups into aromatic compounds, making it a fundamental tool for the synthesis of various valuable organic molecules.
Reimer-Tiemann Reaction can be used to synthesize a variety of ortho-hydroxy benzaldehydes, which are important precursors to a variety of other products, such as pharmaceuticals, dyes, and flavorings. Let’s dig deeper into Riemer Tiemann’s reaction discovered by German scientists and explore its mechanism, applications, and more through this article.
Table of Content
- What is Riemer Tiemann Reaction?
- Mechanism of Riemer Tiemann Reaction
- Difference of Riemer Tiemann Reaction With Other Reactions
- Applications of Riemer Tiemann Reaction